Solvent Effects in Urethane Formation

Abstract

The spontaneous reaction of phenyl isocyanate with 1-butanol was carried out in various solvents. The second-order rate constants for urethane formation were correlated, to a certain extent, to the dielectric constant and the polarity parameter of solvents. Although it was investigated whether the rate constants have correlations to the solubility parameter and th e h ydrogen-bonding one of solvents, the existence of a well-defined linear relationship between them was not observed.