Adsorption Ability of Immune Complex by Hydrophilic Polymers

Abstract

Polyethylene glycol (PEG) is known to precipitate immune complexes in plasma and is use4, for the analytical determination of immune complexes. This interaction of PEG wa s used to separate immune complexes by incorporating PEG in network polymers. PEG with various molecular weights reacted with triisocyanate to form network polymers and the adsorption behavior of plasma proteins was investigated. It was found that the amount of adsorbed plasma proteins was dependent on the degree of swelling of the PEG-containing polymers and selective adsorption of immune complexes on the PEG-containing polymers was observed.