Structural Studies of a Novel Macrolide Antibiotic, Notonesomycin A

Abstract

Notonesomycin A is an antifungal antibiotic isolated from Streptomyces aminophilis subsp. notonesogenes 647-AV, and is effective against shealth blight disease of rice plant.
The structure of notonesomycin A has been elucidated on the basis of the NMR spectral data together with biosynthetic evidences using ¹³C-¹³C double precursors.
Thus the unique structure of the antibiotic containing sulfate ester in the 32-membered lactone ring has been established.