Separation of Picoline Isomers by Clathrate Complex Formation

Abstract

Separation of β- and γ-picolines by clathrate complex formation with 1, 1, 6, 6-tetraphenyl -2, 4-hexadiyne-1, 6-diol [1] and 1, 1, 2, 2-tetraphenyl-1, 2-ethanediol [2] has been studied. Studies on selectivity of inclusion of [1] and [2] for picoline isomers using various kinds of picoline mixtures showed that β-picoline is included predominantly when its content in a mixture is higher and γ-picoline is included predominantly when its content is higher. This selectivity changed depending on the ratio of host: picoline and on the kind of solvent. It was finally clarified that β- and γ-picolines can be easily separated by using the above phenomena.