CI-C, Bond Cleavage of Grayanotoxin III Using Some Organic Acids as Catalyzer -Investigation on Grayan otoxins. VIII-

Abstract

Treatment of grayanotoxin (G)III With oxalic acid in methanol gave G-II iso-G-==II and 1, 5-seco derivative. The structure of 1, 5-seco derivative was identified by comparison of its IR and NMR spectra with those of 3, 6, 14, 16-tetrahydroxy-5, 10-seco-ent-kaurl (10)-en-5-one. It was clarified that the 1, 5-seco compound was an intermediate in the transformation of G-III to G-II and iso-G-II.