Abstract
Tebufenpyrad was discovered by Mitsubishi Chemical Corporation during intensive research on pyrazole derivatives in 1987 and was successfully used in France, Belgium, Switzerland, and then Japan in 1993. Tebufenpyrad is a novel acaricide belonging to the pyrazolecarboxamide group and has high activity against various mite species including Tetranychus spp. and Panonychus spp. due to its rapid action at all development stages of mites. This paper describes the drug design for tebufenpyrad, lead generation, lead optimization, structureactivity relationships of pyrazole-5-carboxamide derivatives; physical and chemical properties, biological characteristics, and the synthesis of tebufenpyrad.
