Disinhibition in developmental disorders revealed by cognitive neuroscience

Abstract

In current neuropsychological theory, the core symptoms in developmental disorders are considered to be caused by abnormal selection and maintenance of motor response to stimuli, due to a failure to inhibit or delay behavioral responses, which are also hypothesized to lead to secondary impairment in executive functions. Evidences of disinhibition in developmental disorders came from neuropsychological tasks, such as memory-guided saccade task, continuous performance test, and Markov decision task using neurophysiological methods（saccade eye movement, NoGo potential, and sympathetic skin response）. In addition, emotional autonomic response is a critical requirement for decision making of future outcomes