Abstract
Objective: We compared the prevalence of colorectal adenoma (adenoma) in men and women and examined lifestyle-related factors and the risk of adenoma according to age and gender.
Methods: Over a 15-year period, 16,647 subjects underwent colonoscopy for the first time at the Health Care Center of Takano Hospital. An association between adenoma and risk factors, such as age, gender difference, BMI, Total-cholesterol (Tcho), HDL-cholesterol (HDL), Triglycerides (TG), LDL-cholesterol (LDL), fasting blood-sugar levels (FBS), and waist-circumference (WT), was investigated. The odds ratios (OR) were calculated by multivariate logistic regression analysis.
Results: A significant increase in the risk of adenoma of 1.03 times was noted when age was considered for both men and women. When the OR for occurrence of adenoma in women was set at 1, the OR in men was 2.52, which was significantly higher. The OR for developing adenoma in men with BMI≧25 was 1.270, and increased by 1.001 for TG; 1.003 for FBS; and by 1.016 for WT. However, each increase in HDL lowered the risk by 0.994. Each increase in TG, LDL, and WT, increased the risk in women by 1.002, 1.003, and 1.019, respectively.
Conclusions: The risk of developing adenoma was enhanced by the male gender, age and increase in visceral fat. This suggests that recognizing that there are certain controllable and uncontrollable factors might contribute to reducing the risk of developing adenoma.
