Abstract
Objective: We previously reported that fasting insulin concentration (F-IRI) plays an important role not only in diabetes but also in all other lifestyle related diseases. We also determined body mass index (BMI) to be a predictor of high F-IRI and showed that changes in F-IRI were correlated with changes in body weight. Furthermore, we observed F-IRI to be closely correlated with the homeostasis model assessment of insulin resistance (HOMA-R). The present study was conducted to find the greatest independent predictor of high F-IRI.
Methods: The subjects were 744 adults whose F-IRI had been measured and visceral fat area calculated from a CT scan. We performed multiple regression analysis to determine the most significant predictor of a high F-IRI.
Results: F-IRI was found to be more significantly correlated with visceral fat area than with subcutaneous fat area but total fat area was found to be the biggest independent predictor of a high F-IRI based on multiple regression analysis. Also, change in F-IRI was more strongly correlated with change in subcutaneous fat area than it was with change in visceral fat area.
Conclusions: These results suggested that both visceral fat and subcutaneous fat affect insulin resistance.
