Abstract
Objective: It has been reported that vital capacity is an independent negative risk factor of metabolic syndrome-related diabetes in Western countries. We investigated an association between vital capacity and metabolic syndrome and diabetes in Japanese subjects since few studies of this type have been conducted in Japan.
Methods: We analyzed medical check-up data from 1,880 men and 1,079 women to determine if there was an association between % vital capacity (%VC) and diabetes and metabolic syndrome (MS) as described in the revised NCEP definition and Japanese MS (JMS) as described in the definition of the Examination Committee for Criteria of Metabolic Syndrome.
Results: For men, %VC was significantly lower in MS subjects than in non-MS subjects (p < 0.0001) but this was not so for women. The prevalence of diabetes, MS, and JMS decreased linearly through the quartiles of %VC in men, but not in women. In men, %VC was significantly negatively correlated with high-sensitivity C-reactive protein (hs-CRP), white blood cell count, alanine aminotransferase, triglycerides, estimated glomerular filtration rate (eGFR), body fat% and fasting glucose and significantly positively correlated with high-density lipoprotein cholesterol, and in women, it was significantly positively correlated with BMI, body fat%, and waist circumference and significantly negatively correlated with hs-CRP, eGFR, and heart rate.
Conclusions: These findings suggest that the prevalence of diabetes, MS, and JMS increased in parallel with a decrease in %VC in Japanese men, but not in Japanese women.
