Abstract
Background The associations between hs-CRP and metabolic risk factors, metabolic syndrome (MS), diabetes, and chronic kidney disease (CKD) were poorly studied in Japanese.
Methods MS-related risk factors, MS defined by revised National Cholesterol Education Program (NCEP) criteria for Japanese, Japanese metabolic syndrome (JMS), diabetes, and CKD were compared between subjects with the highest quartile of hs-CRP (Q4) and those with the lowest quartile of hs-CRP (Q1) using medical check-up data from 1880 men and 1079 women. Diabetes was defined as fasting glucose ≥126 mg/dl and/or antidiabetic medication. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 and/or proteinuria.
Results BMI, body fat %, waist circumference, systolic and diastolic BP, fasting glucose, TG, hs-CRP, gamma glutamyltransferase, ALT, LDL cholesterol, uric acid, WBC count, and heart rate were significantly higher and HDL cholesterol and eGFR were significantly lower in MS subjects than in non-MS subjects in both men and women. % vital capacity was significantly lower in MS subjects than in non-MS subjects in men. The prevalence of MS, JMS, and CKD was significantly higher in Q4 than in Q1 in both men and women and the prevalence of diabetes was significantly higher in Q4 than in Q1 in men, but not in women.
Conclusion The prevalence of MS, JMS, and CKD was significantly higher in Q4 than in Q1 in both men and women and the prevalence of diabetes was significantly higher in Q4 than in Q1 in men. (Ningen Dock 2010; 24: 13-20)
