Examination in Ningen Dock Enhances Rate of Early Diagnosis of Hepatocellular Carcinoma

Abstract

Objective: The purpose of this retrospective cohort study was to clarify the differences between hepatocellular carcinoma (HCC) detected in Ningen Dock when there are no symptoms and that diagnosed after the onset of symptoms.
Methods: Inclusion criteria were HCC and no history of malignant tumor. Our subjects were 87 patients diagnosed with HCC in Ningen Dock when they had no symptoms (Ningen Dock group) and 167 patients who were diagnosed with it after the onset of symptoms (Symptom group). We studied the differences between the Ningen Dock group and Symptom group regarding clinical backgrounds, cancer staging, and survival probability, evaluating differences in clinical backgrounds and cancer staging by the Mann-Whitney test or Kruscal/Wallis1 method. Survival probability was assessed using the Kaplan-Meier method and Cox proportional hazard regression analysis.
Results: 1.Clinical backgrounds: The indocyaningreen retention test at 15 min was 31.9 in the Symptom group and 27.2 in Ningen Dock group (P = 0.011). Stage 1 and 2 accounted for about 30% in the Symptom group, whereas they accounted for about 80% in the Ningen Dock group 2. Survival probability: Survival probability in Symptom group was 60.2% at one year, 31.5% at three years, and 14.4% at five years while that in the Ningen Dock group was 94.6% at one year, 76.2% at three years, and 64.8% at five years. Survival probability in the Ningen Dock group was therefore markedly higher than in the Symptom group.
Conclusion: Evaluation in Ningen Dock enhances the rate of early diagnosis of hepatocellular carcinoma.