Clinical Study on Colorectal Neoplasm Discovered by Total Colonoscopy in Ningen Dock

Abstract

Objective: Our objective was to clarify who should undergo screening for colorectal neoplasm (colorectal polyp and cancer) by total colonoscopy in ningen dock.
Methods: 304 of 3,055 ningen dock patients underwent optional total colonoscopy screening for colorectal neoplasm at our hospital from January 2003 to December 2007. First, we investigated an association between fecal occult blood test and colonoscopy findings. We also determined the risk factors of colorectal neoplasm among the clinical factors of age, family history, past history, smoking history, drinking history, hypertension, diabetes mellitus, dyslipidemia, hyperuricemia and body mass index. Statistical analysis was performed using multivariate analysis (multiple logistic regression analysis) with p<0.05 regarded as significant.
Results: The fecal occult blood test revealed 2 of 4 cases of colon cancer (including 1 case of advanced colon cancer), missing 2 cases of early colon cancer. The independent risk factors were past history (odds ratio 1.882, 95% CI: 1.104-3.209) and drinking history (odds ratio 1.912, 95% CI: 1.120-3.266). Furthermore, patients who had more than two factors among hypertension, dyslipidemia, family history, obesity (BMI≧25), hyperuricemia, age (over 50 years) and smoking history, were considered to have a significantly high risk of colorectal neoplasm.
Conclusions: Patients who have a past history of colorectal neoplasm or drinking history or more than 2 factors among hypertension, dyslipidemia, hyperuricemia, age (over 50 years) and smoking history should be encouraged undergo total colonoscopy for screening for colorectal neoplasm in ningen dock.