Abstract
Objective: The aim of this study was to examine the relationship between metabolic syndrome (MetS) and anti-aging medical indicators such as functional age and oxidative stress markers.
Methods: The subjects were 175 persons who underwent an anti-aging evaluation. The functional age parameters considered were muscle age (weight bearing index), bone age (bone mineral density (BMD), hormone age (IGF-I, DHEA-s/cortisol ratio), blood vessel age (pulse velocity analysis, homocysteine and hsCRP), urine 8-OHdG and oxidative stress prevention potential index (OSPPI). Cross-sectional statistical analysis was performed on them.
Results: Fifteen men (age 67.2±8.1) and 7 women (age75.9±11.2) were assigned to a MetS (+) group and 55 men(age 62.9±11.8) and 80 women(age 63.8±12.1) to a MetS(-) group. In the MetS (+) group, muscle age tended to be higher. BMD was higher (P=0.009) in men but lower in women (P < 0.001). BMD was not significantly associated with smoking habit or other factors. In the MetS(+) group, DHEA-s was lower in men (P=0.048) and women had a significantly lower DHEA/cortisol ratio (P=0.013). In women in this group, homocysteine levels were higher (P=0.010), and hsCRP levels were also higher (P=0.019). Levels of 8-OHdG were higher in MetS (+)women (P=0.010) while serum LPO was higher in men in this group (P=0.028). The OSPPI was lower in the MetS(+)group, particularly in women (P=0.020).
Conclusion: Our data indicate that MetS can affect functional aging which is partially mediated by oxidative stress.
