Abstract
Objective: To study associations between changes in body weight (dBW), body mass index (dBMI), and waist circumference (dWC) and changes in systolic blood pressure (SBP) (dSBP), diastolic blood pressure (DBP) (dDBP), fasting plasma glucose (FPG) (dFPG), triglycerides (dTG), HDL cholesterol (dHDL), LDL cholesterol (dLDL), and high-sensitivity C-reactive protein (hsCRP) (dCRP) over 1 year.
Methods: Our subjects were 1,557 men and 817 women with each cardiovascular risk factor (SBP >= 130mmHg, DBP >= 85mmHg, FPG >= 100mg/dL, triglycerides >= 150mg/dL, HDL < 40mg/dL in men and < 50mg/dL in women, LDL cholesterol >= 140mg/dL, or hsCRP >= 0.4mg/L in men and >= 0.35mg/L in women). Those who ceased taking relevant drugs or were newly prescribed with such drugs during the follow-up period were excluded. Multivariate linear regressions were individually calculated between changes in the risk factors as dependent variables and dBW, dBMI, and dWC as independent variables.
Results: The standardized regression coefficients of dBW, dBMI, and dWC, for dSBP, dFPG, dTG, dHDL, and dLDL were 0.124 (p=0.005), 0.132 (p=0.003), and 0.115 (p=0.009), 0.204 (p<0.0001), 0.189 (p=0.0001), and 0.167 (p=0.001), 0.067 (p=0.183), 0.145 (p=0.004), and 0.131(p=0.008), -0.263 (p=0.006), -0.271 (p=0.004), and -0.224 (p=0.024), and 0.280 (p<0.0001), 0.227 (p<0.0001), and 0.150 (p=0.005), respectively, in men. There were no significant associations between dBW or dWC and changes in risk factors in women.
Conclusions: In men, the associations of dBW with dFPG, dHDL, and dLDL tended to be stronger than those of dWC, while dWC and dBMI, but not dBW, were significantly associated with dTG.
