Effect of Olive Polyphenol Dry Extract on Glucose Metabolism in Subjects with Hypertension

Abstract

Objective: It is commonly known that diabetes in combination with hypertension increases the risk of stroke and heart disease. It is therefore important to try and prevent the onset of diabetes in hypertensive patients. In the present study, we examined the effect of water-soluble olive polyphenol (OPDEX) on blood glucose levels in hypertensive patients with impaired glucose tolerance.
Methods: We had 15 hypertensive patients with impaired glucose tolerance take a supplement containing OPDEX for 12 weeks and conducted routine laboratory tests and measured oxidative stress indicators before and after taking the supplement.
Results: After 12 weeks of taking OPDEX, we observed a significant reduction in fasting glucose levels. Also, HOMA-β levels tended to be increased.For all other parameters, there were no significant differences with a placebo group for before and after taking the supplement.
Conclusion: OPDEX was clearly effective in reducing blood glucose levels in hypertensive patients with impaired glucose tolerance. The mechanism of action was considered to involve inhibition of α-glucosidase activity by OPDEX as well as its insulin secretion improving effect. Our findings suggested that OPDEX could help prevent or delay the onset of diabetes in hypertensive patients with impaired glucose tolerance.