Abstract
Objective: While NT-proBNP (N-terminal pro-brain natriuretic peptide) has been clinically established as an important biomarker regarding diagnosis, and evaluation of treatments and prognoses in cardiac failure, it still does not have a clear role in health check-ups. We have introduced NT-proBNP measurement as an option in Ningen Dock, and investigated its significance.
Methods: We targeted 599 persons (362 males, 237 females) who had taken advantage of NT-proBNP measurement between August, 2011, when it was introduced, and October, 2012. Regarding these people, we investigated relationships between age, gender, blood pressure, blood chemistry data, ECG findings, cardiothoracic ratio and NT-proBNP measurements.
Results: NT-proBNP was ≥ 125pg/ml (cardiac disease suspected) in 8.8% of the males and 9.7% of the females．NT-proBNP gradually increased with age, and there was a difference between males and females. A positive correlation was seen between NT-proBNP and serum creatinine, and a negative correlation between NT-proBNP and the 3 parameters of albumin, hemoglobin concentration and LDL-cholesterol. So, we considered that NT-proBNP had increased due to stress on heart muscle caused by such conditions as hypoalbuminemia and anemia. NT-proBNP was also increased when ECG findings were left ventricular hypertrophy and arrhythmia but this was not statistically significant.
Conclusion: NT-proBNP reflects stress on heart muscle. This test may therefore complement cardiac function exams in Ningen Dock, i.e. electrocardiograms and chest X-rays.
