Abstract
Objective: The aim of this study was to cross-sectionally examine factors associated with decreased eGFR in the case of a trace protein readings in urinalysis by dipsticks.
Methods: Associations of trace proteinuria and metabolic syndrome-related factors, such as BMI, abdominal circumference and blood pressure, with decreased eGFR were examined by logistic regression analysis using specimens from 20,340 subjects (men: 11,948, women: 8,392, average age: 52 ± 11) who underwent a health check-up at The Niigata Health Care Association in the period from 2008 to 2013.
Results: Logistic regression analysis including all factors demonstrated that BMI and proteinuria were significantly related to decreased eGFR. In a further study concerning the additional effect of trace proteinuria and BMI ≥ 25 on decreased eGFR, the sex- and age-adjusted odds ratio was 2.04 (95% confidence interval (CI); 1.44, 2.90) in the trace proteinuria positive and BMI ≥ 25 group in comparison with the proteinuria negative and BMI < 25 group.
Conclusion: The co-existence of BMI ≥ 25 with trace proteinuria was shown to increase the prevalence of decreased eGFR.
