2017 Volume 31 Issue 5 Pages 681-688
Background: AminoIndex® Cancer Screening (AICS) is based on AminoIndex® Technology, which involves multivariate analysis of differences in plasma amino acid concentrations between cancer patients and healthy subjects. It has been developed as a novel cancer screening technique which evaluates the probabilities of seven-types of cancer incidence in examinees and determines whether they require further testing or not. We previously reported the frequency of rank C, the rank that requires detailed examination, among 799 examinees, and the results of detailed examinations. In this study, we report the distribution of AICS ranks, the results of detailed examinations of rank C subjects and positive predictive values for a larger cohort of 5,172 examinees.
Methods: The distribution of AICS ranks, the results of detailed examinations for rank C subjects and positive predictive values were investigated in 5,172 examinees at Mitsui Memorial Hospitals.
Results: One lung cancer patient, 3 gastric cancer patients, 3 colorectal cancer patients, 6 prostate cancer patients and 4 breast cancer patients were found through detailed examination of rank C subjects. The positive predictive values for AICS (lung), AICS (gastric), AICS (colorectal), AICS (prostate), AICS (breast) and AICS (uterine/ovarian) were 0.37%, 0.75%, 1.19 %, 1.80 %, 3.57% and 0 %, respectively. The detection rate of cancer by AICS was 0.33%, which was superior to that of 0.26% reported in the results of the national survey by Japan Society of Ningen Dock in 2015.
Conclusion: These results suggested that AICS could be a useful, novel cancer screening method.