Abstract
In our present world, both overnutrition and undernutrition are important issues that need to be addressed. Overnutrition increases the incidence of metabolic syndrome and lifestyle-related diseases, while undernutrition due to loss of appetite in the elderly or extreme weight-loss diets in young women leads to loss of skeletal muscle. Early detection of these risks followed by appropriate interventions are critical in preventing serious diseases like cardiovascular and cerebrovascular diseases as well as locomotive syndrome.
Several recent studies have reported that when there is the risk of future development of lifestyle-related diseases due to overnutrition, plasma amino acid profiles are altered in a certain way while malnutrition alters them in a different way. Based on such findings, in other studies, multivariable models using amino acid concentrations were developed for use as screening tests and their performance was evaluated. Among the screening tests focused on in these studies, we review the performance of AminoIndexTM Lifestyle Related Diseases Risk Screening in detecting undernutrition and predicting the risk of developing diabetes within four years due to overnutrition.
