Abstract
Objective: Based on multivariate analysis of plasma amino acid concentrations between cancer patients and healthy subjects, AminoIndexTM Cancer Screening (AICSTM) is used to evaluate the probabilities of people having seven types of cancer. In this study, we report annual changes in AICS ranks and cases of cancer detected in subjects determined to have changed to rank C in the annual screening by AICS.
Methods: Annual AICS rank changes were investigated in 216 subjects (115 Men, 101 Women) examined twice and in 139 subjects (81 Men, 58 Women) examined three times (average examination interval: 1.0±0.1 year). Numbers of cases of cancer detection among subjects determined to have changed to rank C in annual screening were investigated.
Results: The rank change rate results for A→C, B→C and C→C in the annual AICS screening were as follows. AICS (lung): 0.5%, 3.7%, 2.8%, AICS (gastric): 6.9%, 5.1%, 4.6%, AICS (colorectal): 6.0%, 1.9%, 0.9%, AICS (prostate): 4.3%, 8.7%, 11.3%, AICS (breast): 2.0%, 3.0%, 4.0%, AICS (uterine/ovarian): 2.3%, 1.1%, 0%, respectively. Among subjects examined twice, in an AICS (gastric) group with an annual change of B→C, 2 cases of gastric cancer were found. In an AICS (breast) group with a change result of C→C, 1 case of breast cancer was found. In an AICS (colorectal) group with a change of A→C, 1 case of GIST was found. Among subjects examined three times, in an AICS (prostate) group with annual changes of A→B→C, 1 case of prostate cancer was found. In an AICS (breast) group with annual changes of A→A→C, 1 case of breast cancer was found. The cancer detection rate by AICS was 1.7%.
Conclusion: Although the rate of change to rank C in the annual AICS screening was low, various cancers were discovered in subjects changing to rank C. These results suggest that annual AICS screening may lead to early detection of cancer.
