2018 Volume 33 Issue 1 Pages 22-28
Objective: In prostate cancer screening in Ningen Dock, the PSA test is continuously carried out, enabling us to obtain a PSA curve for every man. Among examinees who underwent the Ningen Dock of Kurosawa Hospital, we compared PSA growth curves between normal men and prostate cancer patients.
Methods: The PSA growth curves of all male examinees (n=138,392, 30 to 79 years old) of the Ningen Dock at Kurosawa hospital were investigated. PSA growth curves were also investigated in 69 men who were found to have prostate cancer.
Results: PSA growth curves in men with prostate cancer were quite different from those without. In the former, there were three phases of PSA growth: a flat phase, a gently increasing phase and a sharply increasing phase. The pre-biopsy PSA, PSA doubling time (2nd + 3rd phase) and the duration of the 3rd phase affected the Gleason grade group.
Conclusion: If the 3rd phase, the PSA sharply increasing phase, is seen in an examinee, examination by a urologist should be recommended.
