2018 Volume 33 Issue 1 Pages 35-42
Background: AICS (prostate) was developed based on “AminoIndex Technology”. It involves multivariate analysis of the plasma free amino acid (PFAA) concentration between prostate cancer patients and healthy subjects, and has recently been put into use as a screening test for prostate cancer. To clarify the characteristics of AICS (prostate) in screening, we evaluated post-operative changes in AICS (prostate) results in patients who underwent radical prostatectomy for prostate cancer.
Methods: Plasma samples were obtained from 64 recurrence-free patients who underwent radical prostatectomy for prostate cancer at Kanagawa Cancer Center, and compared with preoperative measurements. PFAA concentrations were measured by liquid chromatography-mass spectrometry. AICS (prostate) values and ranks were calculated using the developed index.
Results: After radical prostatectomy, AICS (prostate) values and ranks decreased in 88% (49/56) and 75% (42/56) of recurrence-free patients determined to be rank B or C before prostatectomy, respectively. For preoperative AICS (prostate) rank C patients, postoperative AICS (prostate) values and ranks decreased in 93% (39/42) and 79% (33/42), respectively.
Conclusion: The AICS (prostate) value and rank decreased in most patients after radical prostatectomy. As AICS (prostate) results reflect prostate cancer development, they could be a useful cancer screening marker.
