2018 Volume 33 Issue 3 Pages 440-446
Objective: AminoIndexTM Cancer Screening (AICSTM), based on plasma amino acid concentrations between cancer patients and healthy subjects, has been developed as a screening test for seven types of cancer. In this study, associations between AICS ranks and lifestyle habits were investigated to clarify the clinical significance of AICS for cancer prevention.
Methods: AICS values were calculated in 10,102 subjects at Mitsui Memorial Hospital. They were divided into two groups for each parameter based on their answers in an interview card regarding lifestyle habits as well as BMI and diabetes-related parameters, and associations between lifestyle habits and odds ratios that there was at least one rank C in all AICS were determined.
Results: The odds ratio that there was at least one rank C in all AICS was significantly higher in the little or short duration exercise group than frequent or long duration exercise group, in the irregular mealtime group than regular mealtime group, in the groups hardly eating any fish, soy beans, milk/dairy products, fruit, or seaweed than groups eating these foods everyday, in the high alcohol consumption group than low alcohol consumption group, in the smoking group than non-smoking group, in the insufficient sleep group than sufficient sleep group, in the inappropriate BMI group than appropriate BMI group, and in the diabetes group than non-diabetes group.
Conclusion: These results suggested that there was an association between lifestyle habits related to cancer risk, such as exercise and dietary habits, smoking, alcohol intake, obesity, diabetes, and AICS ranks. Lowering cancer risk by improving lifestyle habits could improve AICS ranks, resulting in cancer prevention.
