Association between Helicobacter pylori Infection and Colorectal Adenoma in Japanese Male Population

Abstract

Objective: We examined an association between Helicobacter pylori (H. pylori) infection and colorectal adenoma (CA), including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and lifestyle factors as covariates.

Methods: A total of 44,254 Japanese males underwent a comprehensive health check-up at our facility between April 2013 and March 2017. Among 2,662 subjects positive for the fecal occult-blood test, 1,450 underwent total colonoscopy. Subjects aged less than 40 years, those who did not undergo esophagogastroduodenoscopy screening or VAT/SAT measurement or who were diagnosed with colorectal cancer or inflammatory bowel diseases were excluded. The final number of subjects enrolled for this cross-sectional study was 990 (mean age: 55.3 years). The association of H. pylori antibody serostatus and endoscopic gastritis with CA was investigated using multiple logistic regression analysis.

Results: Rates of H. pylori antibody seropositivity and chronic gastritis were higher in those with CA compared to those without (20.4% and 54.2% vs 13.0% and 34.7%, p<0.01 and <0.01, respectively). There was a significant, independent association between H. pylori antibody seropositivity and CA (OR=1.595, 95%CI=1.093-2.327, p=0.015) in Model 1. Similarly, there was a significant, independent association between chronic gastritis and CA (OR=1.97, 95%CI=1.46-2.65, p<0.01) in Model 2. Age and VAT were predictors of CA in both Models. Alcohol and smoking habit increased the prevalence of CA in both Models, and exercise reduced it.

Conclusions: The prevalence of CA was significantly and independently increased by H. pylori infection in a Japanese male population, after adjusting for metabolic parameters and lifestyle factors.