2020 Volume 34 Issue 5 Pages 693-701
Objective: The aim of the present study was to examine the influence of Helicobacter pylori (H. pylori) infection on multiphasic health check-up data.
Methods: Among individuals who received a multiphasic health check-up at Takagi hospital, we included those who underwent a serum anti-H. pylori IgG test. Those who had received H. pylori eradication therapy and had comorbidities were excluded. There were a total of 1,816 subjects in the present study (H. pylori negative: 907, H. pylori positive 909), consisting of 970 men (positive, 51.2%), and 846 women (positive, 48.7%).
Results: Data were analyzed by the multiple regression technique after adjusting for age. A significant difference between H. pylori negative and positive was observed for the following factors: WBC (p < 0.001, β = 243.84), HDL-C (p = 0.002, β =–2.17), LDL-C (p = 0.003, β = 3.94), platelets (p = 0.007, β =0.62), Hb (p = 0.024, β = –0.16). In men, a significant difference between negative and positive was observed for Hb (p = 0.003, β = –0.2) and in women, there were significant differences for WBC (p < 0.001, β = 372.27), HDL-C (p = 0.002, β = –2.98), Hb (p = 0.014, β = –0.19), platelets (p = 0.015, β = 0.85), and LDL-C (p = 0.028, β = 4.23).
Conclusion: Blood cell counts and serum lipids were influenced by H. pylori infection, and the effect of H. pylori was more potent in women than in men.
