2020 Volume 35 Issue 2 Pages 170-176
Objective: To report an adult case of transient hyperphosphatasemia, which has been reported to be rarely asymptomatic.
Methods: A healthy male in his early thirties underwent a one-day health check-up. Although he had a previous medical history of diarrhea, abdominal pain, rash, and fever of unknown etiology, he was asymptomatic at the health check-up.
Results: The health check-up revealed an abnormally high ALP level of 1,297U/L, but the other test results were normal. During follow-up as an outpatient, the ALP level decreased to 591U/L after six days and to 327U/L after 14 days. Several examinations were unable to identify background disorders of hyperphosphatasemia. The ALP isozyme test revealed a fast α2 band specific to transient hyperphosphatasemia in the serum at the health check-up. The band remained slightly after 14 days.
Conclusion: Transient hyperphosphatasemia can occur in asymptomatic adults. Additionally, the ALP isozyme test may be useful for the diagnosis of transient hyperphosphatasemia even if the ALP level decreases.
