2020 Volume 35 Issue 2 Pages 203-209
Objective: The aim of this study was to analyze the effects of weight changes over 5 years on the risk of developing hypertension, diabetes mellitus, and high non-HDL cholesterol levels.
Methods: The study subjects were men with BMI ≥ 25kg/m2 or waist circumference ≥ 85cm. They were divided into 7 groups based on the change in their weight over a period of 5 years: >5% gain, 3%–5% gain, 1%–3% gain, stable weight, >5% loss, 3%–5% loss, 1%–3% loss. We analyzed the subjects’ risks of developing hypertension, diabetes mellitus, and high non-HDL cholesterol using logistic regression analysis.
Results: A significant risk reduction was observed in the >5% weight loss group [odds ratio (OR)=0.60] for hypertension; for three weight loss groups of 1%–3% (OR=0.42), 3%–5% (OR=0.26), and >5% (OR=0.12) for diabetes mellitus; and for two weight loss groups of 3%–5% (OR=0.42) and >5% (OR=0.33) for high non-HDL cholesterol compared to the stable weight group.
Conclusion: Our results suggest that, compared to those with stable weight, men who lost more than 5% of their body weight have significantly reduced risk for all three diseases.
