Significance of Personal Predisposition and Possibility of Genetic Polymorphism Related with Lifestyle Factor for Health Management

Abstract

CYP1A1 (Ile462val), ALDH2 (glu487lys), β3ADR (trp64arg) gene polymorphism-single nucleotide polymorphism (SNP) related with life style factor-smoking, drinking, obesity are detected in 128 Japanese subjects who are willing to have the health check. Each frequencies of atypical zygote are 35%,59%,35% respectively and normal homozygote on the three genes is only 20%, but atypical zygote more than two is 45%. That indicates existence of personal predisposition of sensibility for the lifestyle factor. Furthermore we need personalized medical intervention for health management.