Abstract
Objective and Methods: We evaluated whether to detect the prostate cancer of young men (under 70 years old) at the early stage (moderately or poorly differentiated carcinoma)efficiently by using the prostate specific antigen (PSA) test. The first trial tests were performed in Kanagawa Health Service Association. Re-tests were performed on the patients whose results showed a level higher than 3.0 ng/ml PSA. The second trail tests were performed in Kanagawa Cancer Center. Results: In total,5,655 men (the average age was 57.3 years old) received the PSA test during 7 years between April 1998 and March 2005. The result showed that 499 men (8.8%) had the PSA levels higher than 3.0ng/ml. From those,114 men(2%)received the second examination. Of those,72 men received needle biopsy. Prostate cancer was detected in 24 men (0.42%, the average age was 65.5years old). Conclusions: The cancer detection rate was rather low (0.42%) probably because the trial group was a relatively younger generation. The PSA F/T, PSA density (PSAD) and the PSA velocity (PSAV) are possibly the useful methods in order to improve the cancer detection rate in the screening.
