Abstract
Objective: The inflammatory process is considered to be partly involved in the pathogenesis of type 2 diabetes. An increased level of high-sensitivity CRP (hs CRP) was investigated regarding whether this has any relation with abnormal glucose and insulin metabolism. Methods: 4354 subjects, who showed minimal variation in hs CRP from Jan.2002 through July 2005, were recruited and divided into three groups based on the hs CRP concentration: lower (<1. Omg/L), middle (1.0-1.99mg/L), and higher (>2.0mg/L) groups. Fasting blood glucose, insulin, and HbA1C were measured and HOMA-R was calculated. Results: In the higher hs CRP group, insulin, HOMA-R, glucose, and HbA1C were elevated. Adjusting BMI in the three groups, insulin, HOMA-R, glucose, and HbA1C were also elevated in the middle and higher groups compared to the lower group. Conclusion: Increased hsCRP levels are more effective to predict the development of future abnormal glucose metabolism than BMI.
