Original Article
Polymorphism of (Pro)renin Receptor Gene is Associated with Renal Function in Japanese Women
2014 Volume 2 Issue 1 Pages 3-8
Details
2014 Volume 2 Issue 1 Pages 3-8
Objective: (Pro)renin receptor (PRR), a specific receptor for renin and prorenin, has been identified as a new member of the renin-angiotensin system (RAS). We investigated an association between the rs5918007 PRR gene polymorphism and renal function in Japanese healthy subjects.
Methods: This study enrolled 472 Japanese subjects (288 men and 184 women) who underwent health check-ups at Nagoya University Hospital. The genotyping of the PRR gene single nucleotide polymorphism (SNP) rs5918007 was performed using a polymerase chain reaction with confronting two-pair primers (PCR-CTPP) assay.
Results: In female subjects, the serum creatinine level was significantly low, and estimated glomerular filtration rate (eGFR) was significantly high in (CT+TT) carriers as compared with CC carriers. In male subjects, however, there was no significant difference in serum creatinine or eGFR between the C and T genotype.
Conclusion: PRR SNP might affect renal function in Japanese women.
