“AminoIndex Technology” for Lifestyle-related Disease Risk Screening

Abstract

  Recently, both overnutrition and undernutrition have become social issues. Overnutrition has led to an increase in the number of individuals with metabolic syndrome and lifestyle-related diseases, while undernutrition due to loss of appetite in the elderly or severe weight-loss diets in young women may lead to loss of skeletal muscle. Early detection of these risks followed by appropriate interventions is critical for preventing the development of serious diseases such as cardiovascular and cerebrovascular diseases and locomotive syndrome.

  Recent studies have reported that future risks for developing lifestyle-related diseases include changes in plasma amino acid profiles and that malnutrition changes plasma amino acid profiles in a different manner from overnutrition. Based on these findings, other studies have developed and evaluated the performance of multivariable models based on plasma amino acid concentrations for use as screening tests. We reviewed one of these screening tests (AminoIndex_TM LifeStyle diseases) regarding the development of diabetes within four years as a result of overnutrition as well a status of undernutrition.