2018 Volume 5 Issue 1 Pages 32-37
Objective: Hyperuricemia is an established risk factor of incident hypertension. However, the impact of renal function on the relationship between hyperuricemia and incident hypertension has not been fully elucidated. We investigated the relationship between hyperuricemia and incident hypertension stratified by estimated creatinine clearance (Ccr) or proteinuria using health check-up data.
Methods: We conducted a retrospective cohort study of 11,043 adult males who underwent health check-ups at our institutions and had no history of either chronic renal failure or cerebrocardiovascular diseases. Participants were divided into quartiles according to serum urate levels, and the fourth quartile was defined as the hyperuricemia group (serum urate level ≥ 6.9 mg/dL). We followed up the participants for five years using annual health check-up data.
Results: During 33,672 person-years of follow-up, 1,614 participants developed hypertension. The cumulative incidence of hypertension was significantly different among the quartiles (Log-rank test, p < 0.001). The multivariate Cox proportional hazard model revealed that hyperuricemia was significantly associated with incident hypertension (hazard ratio: 1.346, p < 0.001). In the analyses stratified by proteinuria or Ccr, hyperuricemia was associated with incident hypertension in the proteinuria-negative and proteinuria-positive groups, as well as in the Ccr-high and Ccr-low groups (divided by median of Ccr). Neither proteinuria nor Ccr had a significant interaction with the relationship between hyperuricemia and incident hypertension (likelihood ratio test: interaction p = 0.8747, 0.5638, respectively).
Conclusions: Hyperuricemia was significantly associated with incident hypertension in a healthy male population with no influence from proteinuria or creatinine clearance.
