The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
Symposium—Drug Eruption—
Pathogenesis of Drug Eruption
Katsuyuki TAKEDA
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1969 Volume 31 Issue 2 Pages 105-118

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Abstract
The pathogenesis of drug eruption was studied clinically and experimentally. While no direct evidence for the increased formation of antibodies in patient with drug eruption was obtained the patients with experimentally induced drug eruption were noted with remarkable alteration of immuno-globlin (γG, γA and γM) and the complements titer (C′H50) after and before administration of the suspected drugs, and decrease in white blood corpsules and thrombocytes after causative drugs of hypersensitivity were given. Accordingly, the establishment of sensitizing state due to diathese would be of the first necessity. Among the factors which promote the onset of drug eruption include especially autonomous nerves specifically the parasympathic tension, which intensifies the tendency for exudative inflammation of the skin and scarring. Furthermore, primary and the sencodary liver dysfunction, and the decreased function in the ammonia diposal as well as paticipation of histamin as a chemical mediator which formulate circulus viciosus responsible for advancement in the process of the disease. Finally potentialities of abnormal production of antibody and the promoted reaction in the various organs including the skin play grate role in the pathogenesis of the drug eruption.
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© 1969 by Western Japan Division of JDA
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