Abstract
Urticaria has long been known to be a reaction pattern of the skin which may be produced by a considerable number of individual causes. It is a vascular reaction pattern of the skin characterized by the appearace of transient erythematous or whitisch swelling in the skin. The study of the mechanism of the production of urticaria has been done and the following results were obtained.
1) Among the various chemical mediators histamine might be the most potent to cause the urticaria. It might released from the mast cells surrounding of the capillary bed in upper dermis and caused the urticaria by the vasodilation and the increase of capillary permeability. Most of histamine liberators which release the histamine from mast cell might thought to go through the vessels to dermis in urticaria.
2) Dermographism might caused by kinin rather than histamine.
3) The category of cholinergic urticaria may be necessary to discuss more in Japan.
