The Effect of Commercial Product Soap to the Protein of Epidermis

Abstract

The commercial product soaps were studied in vitro to determine if the soap solutions were capable of affecting epidermal protein. Sodium N-acyl-L-glutamate (AGS) soap, sodium fatty acid soap (A) and lauryl sulfate soap (B) were selected in the present study. The epidermal protein was prepared from the rat at the various months of age. The human stratum corneum was taken from casts removed in an orthopedic clinic. The pathological scale was collected from patient with psoriasis. The sulfhydryl content in the protein solution incubated with soap solution, was determined by the method of amperometric titration. The sulfhydryl concentration in the rat pidermis was definitely altered after incubation in the certain desired concentration of soap solution. However, AGS solution showed the lowest grade of denaturation for the epidermal protein. The sulfhydryl value in the psoriatic scale incubating with soap solution increased above two fold, whereas the AGS solution caused only the thirty percent of increase in sulfhydryl vale. It was found that the AGS soap solution has the mild effect for the normal and pathological protein in the epidermis.