Abstract
Rats were treated with a daily dose of 0.2 g of 0.12 % betamethasone valerate (B-V), 0.025 fluocinolone acetonide (F-A), 0.05 % fluocinolone acetonide acetate (FAA) and 0.05%, clobetasol propionate (C-P) percutaneously for successive two weeks, and the change of body weights, the number of death during the treatment, the effects on thymus, adrenals, spleen and treated region of skin, haemogram and myelogram were compared. The results thus obtained proved to be in the order of FAA>F-A>C-P>B-V, and were not necessarily in parallel with the order of vasoconstriction index by McKenzie's method. In view of above systemic effects observed on any topical corticosteroids at clinical concentrations, although given in considerable amount, careful attention has to be paid to clinical use of topical corticosteroid in a large dose for a longer period.
