Abstract
Electronmicroscopic observation of the nerve fibers, innervated around the secretory segments of eccrine sweat glands at the anhidrotic lesions in two cases of anhidrosis combined with Adie syndrome was carried out, and compared with those of normal persons. The axons revealed no abnormality, but the myelin sheaths, Schwann cells and endoneuriums showed degeneration. These results support the view that the main lesion of this anhidrosis is located in the post-ganglionic fiber and this is one of the diseases which injure principally myelin sheaths and Schwann cells. This anhidrosis beared a resemblance to diabetes mellitus or amyloidosis in the electronmicroscopic findings, as compared with reports on ultrastructures of affected peripheral nerve fibers which showed hypohidrosis. The fact that myelinated nerve fibers which do not innervate sweat glands have degenerative changes may imply that sensory disorders, not recognized clinically, are eventual.
