Abstract
A 75-year-old female with malignant hemangioendothelioma was reported. Clinically, teleangiectasia, edema and multicentric, black, soft tumors in the scalp and the face are characteristics of this disease. Histopathological studies showed malignant proliferation of vascular endothelial cells. Light and electron microscopic histochemistry of the tumor revealed that endothelial cells forming complete or incomplete lumens or proliferating as bundles were positive for alkaline phosphatase activity. However, solitary, cuboidal, and atypical endothelial cells were negative for alkaline phosphatase activity. Chemotherapy failed to cure this patient, although X-ray radiation therapy was slightly effective. The patient, afflicted with this disease for eighteen months, died from deep and wide proliferation and metastases of the tumor to pleura and back bones.
