Four Cases of Extramammary Paget’s Disease

—A Topographic Study—

Abstract

Four specimens from patients with extramammary Paget’s disease (two perineal, one vulvar and one axillary) were studied by means of subserial total sectioning. In all cases, the extent of histologically demonstrable disease was more or less greater than that of the visible lesion. Especially in a case of vulvar Paget’s disease, nests of tumor cells were detected far beyond the margin of the visible lesion. The outline of histologically detectable lesions was irregular and discontinuous in all cases. Microscopic examination also revealed widespread involvement of eccrine sweat ducts and the upper portion of hair follicles.