Abstract
A 54-year-old Japanese woman who developed acanthosis nigricans in the course of pemphigus erythematosus was reported. Two years prior to the first dermatologic consultation at Sagamihara Kyodo Hospital, she noticed bullae and erosions on the face, neck, chest and back following a seborrheic dermatitis-like eruption on the scalp and face. The diagnosis of pemphigus erythematosus was made on the basis of clinical features, histopathological appearance and immunofluolescence findings. Subsequently, she was treated with endoxan and external application of corticosteroid ointment. About nine months later, a papillomatosus brownish eruption occurred in the perioral and periorbital regions, the neck, axillae, wrists and inguinal regions, areas not coinciding with the distribution of pemphigus. Biopsy specimen of the pigmented lesion Showed features of acanthosis nigricans. Despite repeated examinations, no clinical evidence of malignant tumor and endogenous disease was obtained. Acanthosis nigricans associated with pemphigus has been reported very rarely. This may be the first report of acanthosis nigricans in the same patient with pemphigus erythematosus.
