Abstract
A case with malignant lymphoma (diffuse lymphoma, medium-sized cell, B cell type) manifesting Garcin syndrome was described. Histological examination of the cutaneous lesions enabled us to diagnose the disease, since there were no other specific findings in the physical and laboratory examinations. A 66-year-old man had a 4-month history of progressive cranial nerve hemipalsy and increasing cutaneous nodules. The hemiparesis involved the left IIId, IVth, Vth, VIth, VIIth and VIIIth cranial nerves. He also complained of dysosmia. The cutaneous nodules, 10∼23 mm in diameter and bright red in color, were distributed on the face, the chest wall, the left thigh and the left sole. There were no symptoms of increased intracranial pressure and sensorimotor disturbance of the extremeties. Nor were there any abnormal findings in the skull X-ray, the brain computed tomography and the brain magnetic resonance imaging. After the cutaneous nodules were histologically diagnosed, combination chemotherapy was performed. The chemotherapy resulted in a regression of the skin lesions and a slight improvement in the cranial nerve hemipalsy. Nevertheless, the patient died of cachexia 4 months later.
