Abstract
A 54-year-old man was hospitalized because of skin eruptions and fever. He had painful erythematous plaques on his face and trunk. A skin biopsy revealed Sweet’s syndrome. Four months after the eruption first appeared hematological abnormality was discovered and he was diagnosed as myelodysplastic syndrome (RAEB). A biopsy specimen of the skin lesion revealed a dense dermal infiltraion with mature neutrophils including hyperlobulated neutrophils which were also seen in the periferal blood. A chest X-p showed bilateral pulmonary infiltrates. The histology of the lung specimen was similar to that of the previous skin biopsy and it suggested that this patient had Sweet’s syndrome involving the skin and the lung. We examined neutrophil functions of this patient and a hyperproduction of superoxide anion (O2-) was detected.
