Abstract
A case of a 47-year-old male with clear cell syringoma (CCS) is reported. Clear cell syringoma is known as an unusual type of syringoma and is significant that it frequently coexists with diabetes mellitus (DM). In Japan, twenty cases of CCS have already been reported. Seventeen out of the twenty cases with CCS were associated with DM. It has been reported that typical syringoma cells originating from the intraepidermal portion of eccrine ducts were altered to the clear cells by the abnormal cutaneous metabolism due to DM. By various histochemical studies such as CEA and S-100 protein, we found that clear cell-like changes were also demonstrated in the coiled dermal portion of the eccrine ducts.
