Abstract
A rare case of chronic adult T-cell leukemia/lymphoma (ATLL) complicated with malignant melanoma and renal cell carcinoma is reported. A 79-year-old man, born in Fukuoka prefecture, noticed a black-brownish macule on his right sole 20 years before his first visit to our clinic. After admission, continuous leukocytosis (13,000/mm3) with flower cells were found in the peripheral blood. The findings which included increased antibody titers to HTLV-1, positive HTLV-1 proviral DNA, and an appearance of ATLL cells in the cerebrospinal fluids, all support the diagnosis of chronic type ATLL. In addition, renal carcinoma (clear cell type) was histopathologically detected. The patient was treated by five sessions of cryosurgery and immunochemotherapy (dacarbazine, interferon-β), since sole’s macule and inguinal lymph node swelling were consistent with the diagnosis of malignant melanoma (level IV, stage III). These treatments were sufficiently effective to eventually case the macule on his sole to disappear. No appropriate therapies have yet been reported for either ATLL or renal cell carcinoma regarding the patient’s quality of life.
