Abstract
We report a 12-year-old man who developed purpura and bulla in the lower extremities followed by high fever, arthralgia, dry cough, hemoptosis, abdominal pain and diarrhea. The laboratory data revealed proteinuria, hematuria, elevated ESR, eosinophilia, positive reumatoid factor and abnomal shadows in the chest and nasopharingeal X ray examinations. The histological findings revealed leukocytoclastic vasculitis in the skin, pulmonary bleeding in the lung and focal necrotizing glomerulonephritis in the kidney. Prednisolone therapy (PSL; 1 mg/kg/day) failed, but PSL and cyclophosphamide therapy (CPM; 100 mg/day) proved to be markedly effective. After six months of treatment with PSL plus CPM, both the clinical symptons and abnormal laboratory data disappeared.
