Abstract
The case of a 56-year-old woman with polyneuropathy, organomegaly and edema satisfying the criteria for Crow-Fukase syndrome presented with multiple hemangiomas on her trunk and extremities, skin hyperpigmentation and ichthyosis. A histopathologic exarmination of a hemangioma showed proliferating endothelial cells forming immature vascular structures. Plasma exchange treatment led to an improvement in the neuropathy, and the eruptive hemangiomas gradually decreased in both number and size. After the treatment, a specimen from a hemangioma revealed dilated vascular spaces lined by a single layer of flat endothelial cells.
