Abstract
The effect of SM-10902 ointment on the healing of an experimental decubitous ulcer model was examined on the auricle of rabbits. The decubitous ulcer models made by applying pressure (400g/cm2) for 9 hours a day 3-4 times on the rabbit ears until wound lesions were observed. The part of skin that had received the pressure developed necrosis and desquamation of the epithelium, and in some animals the pressed sores became perforated. The decubitous ulcer treated with 1-100μg/g SM-10902 ointment showed a concentration-dependently greater wound closure and rate of healed animals than those treated with its baseointment. Ten and 100μg/g SM-10902 ointment produced a concentration-dependent increase in the skin blood flow at the normal and injured skin in the rabbit auricle. Furthermore, the application of the ointment containing 1 μg/g SM-10902 increased the blood flow in the injured skin, while that of ointment containing 100μg/g had no effect on the systemic blood pressure. These findings suggest that this model is useful for the objective evaluation of the drug on decubitous ulcers and that SM-10902 ointment may thus promote wound healing through an improvement in the blood flow at the injured site without any systemic effects. Therefore, SM-10902 ointment may be useful in the treatment of decubitous ulcers and skin ulcers caused by peripheral circulatory insufficiency.
