Abstract
To evaluate the blood coagulation and platelet agglutination in Behçet’s disease, we estimated the prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), using ADP, collagen and epinephrine in 43 patients with Behçet’s disease and 26 healthy volunteers. A higher level of fibrinogen was found in the active Behçet’s disease patients (P<0.01), compared with the inactive Behçet’s disease patients and healthy volunteers. An elevated level of collagen-induced platelet agglutination in Behçet’s disease patients was also found. These results implied that patients with Behçet’s disease were in hypercoagulable and hyperfibrinolytic states, especially when their diseases were active. These findings can also serve as a useful indicator for the pathological state involved in Behçet’s disease.
